Medical Physiology : The Big Picture (LANGE The Big Picture) by Halsey Colby R. & Jonathan Kibble

Author:Halsey, Colby R. & Jonathan Kibble [Halsey, Colby R.]
Language: eng
Format: epub
Publisher: McGraw-Hill
Published: 2009-01-19T20:00:00+00:00

RENAL TITRATION CURVES

Renal titration curves can be used to determine the maximum rate of solute transport (transport maximum, Tm) for solutes with saturable transport. Construction of a titration curve first requires calculation of the filtered solute load for a range of plasma solute concentrations. Excretion rates are measured from urine samples across the same range of plasma solute concentrations. The net tubular transport is calculated from the difference between the filtered load and the excretion rate. The renal titration curve for glucose is shown in Figure 6-17. The plasma solute concentration at which the solute first appears in urine is called the renal threshold. The glucose reabsorption curve levels off gradually rather than reaching the plateau abruptly. This phenomenon is called splay and is due to variability in the tubular transport maxima between nephrons. The plateau of the glucose reabsorption rate at glucose concentrations that saturate the transport mechanism reveals the Tm for glucose.

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